BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage
نویسندگان
چکیده
منابع مشابه
Regulation of USP7/HAUSP in response to DNA damage
The ataxia-telangiectasia mutated (ATM) protein kinase is widely accepted to play a key role in the DNA damage response, in particular in the signaling of radiationinduced DNA double-strand breaks. In this regard, ATM activates a number of cell cycle checkpoints to delay DNA replication and ensure the correct processing of the damaged DNA. This is achieved both directly, through phosphorylation...
متن کاملTIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1
DNA repair pathways enable cancer cells to survive DNA damage induced after genotoxic therapies. Tyrosine kinase receptors (TKRs) have been reported as regulators of the DNA repair machinery. TIE2 is a TKR overexpressed in human gliomas at levels that correlate with the degree of increasing malignancy. Following ionizing radiation, TIE2 translocates to the nucleus, conferring cells with an enha...
متن کاملATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response. Despite this important role in controlling other proteins, USP7 itself has not been recognized as a target for regulation. Here, we report that USP7 regulation plays a central role in DNA damage signal transmission. W...
متن کاملMDC1 regulates DNA-PK autophosphorylation in response to DNA damage.
DNA damage initiates signaling events through kinase cascades that result in cell cycle checkpoint control and DNA repair. However, it is not yet clear how the signaling pathways relay to DNA damage repair. Using the repeat region of checkpoint protein MDC1 (mediator of DNA damage checkpoint protein 1), we identified DNA-PKcs/Ku as MDC1-associated proteins. Here, we show that MDC1 directly inte...
متن کاملNuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates genes remains unknown. Here we provide evidence that direct association of ING2 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03020-6